Engineer Talk: Building Platforms for Scientific Research
One of our engineers, Damon Doucet, discusses the challenges behind building software that unifies data across many experiments and samples, and that surfaces that data to scientists with rich permissions.
Red Cell Therapeutics: Pioneering a New Era of Cellular Therapies
Tiffany Chen, Director of Discovery at Rubius Therapeutics, discusses the unique data problems presented by red blood cell therapies, and how Benchling is changing the way that Rubius organizes and carries out R&D.
Given the rising costs, protracted timelines, and increasing complexity of large molecule R&D, scientists, group heads, and executives all need to take a data-driven approach to optimizing their own processes and decision-making. In this series, we explore a framework for scientists, group heads, and executives to measure the success of their programs.
Benchling: Bringing Industrialization to the Biotech Revolution
Right now, we're at the start of a biotech revolution comparable to the rise of the computer in the '70s and '80s. We believe that Benchling will be the central force that drives the industrialization of the new biotech economy.
What to Look for in an Informatics Platform for Biologics R&D
Fundamentally, platforms that are effective for biologics R&D must be built from the ground up to address the unique nature of biologics. Learn the five critical capabilities to look for when evaluating an informatics platform for biologics R&D.
The Top 6 Questions Directors of Informatics for Biologics R&D Struggle to Answer
The key success metric of informatics for R&D is improving data integrity and accessibility to support intellectual property. This is particularly important in the emerging modalities of biologics R&D.
Antibodies are an important class of therapeutic agents which have evolved significantly over the past 30 years. Antibody R&D is now more streamlined than ever, but several factors continue to contribute to its complexity. This paper outlines the critical needs and complexities faced during both research and development phases, and how Benchling has helped address these challenges for leading antibody companies.
Obsidian’s legacy sample tracking system was unintuitive and saw low scientist usage, leading to data loss and compliance concerns. Hear how Benchling’s integrated sample tracking and notetaking generated strong user adoption, improved the quality and reliability of experimental records, and empowers Obsidian to extract learnings from their data that they otherwise wouldn’t have.
From California, to Korea, to the Netherlands, companies developing large molecule-based products rely on Benchling to accelerate R&D and generate unprecedented business insights. In this eBook, we cover stories from Incyte, Intellia Therapeutics, Agenus, Warp Drive Bio, Zymergen, Obsidian Therapeutics, and Inhibrx.
Rubius: Optimizing Cell Engineering with a Unified Informatics Platform
Rubius Therapeutics is engineering therapeutic red blood cells to treat a host of diseases, using varied, complex cell engineering processes to do so. Before Benchling, it was difficult for Rubius to unify these discrete steps in cellular engineering, and it left their teams out of sync. After adopting Benchling, Rubius can now collaborate and manage their pipeline, all with one unified platform.
Synlogic: Accelerating Synthetic Biology with Fully Unified Informatics
Synlogic is employing naturally occurring, non-pathogenic bacteria from the human gut microbiome by genetically altering them to function as living medicines. Previously, Synlogic’s legacy software was hindering data processing and reporting. Then Synlogic adopted Benchling, which enabled them to automate and structure their data capture in a single centralized system.
Agenus: Building a global informatics infrastructure
Agenus is a global biopharmaceutical company with scientific staff spread across four discovery, screening, and characterization facilities around the world. Without unified informatics systems, it was difficult for Agenus's scientists to effectively find and share information. Learn how Benchling replaced Agenus's multiple informatics systems with a single, end-to-end platform.
Zymergen: Integrating the custom solutions of a technology powerhouse
Zymergen is an industrial biotechnology company with many custom software systems and algorithms. Prior to adopting Benchling, Zymergen's scientists had to enter and extract data across many siloed pieces of custom software. Today, Zymergen uses Benchling as a central platform to unite their custom tools and collaborate seamlessly across teams.
Arcturus is an industry leader in RNA medicines. Without standardized molecular design tools, scientists struggled to collaborate and share their sequences. And with their legacy ELN, it took an average of 10 days for experimental data to be recorded. With Benchling, Arcturus saw a dramatic increase in scientist collaboration and reduced time to data entry by 85%.
Learn how to model the complexity of any large molecule entity in Benchling Registry. From bacteria and yeast strains, to antibody complexes, Registry can manage any biological entity, reagent, instrument, and more.
Learn how to configure biological entities, locations, inventories, workflows, and reports in Benchling's point-and-click interface. Never wait months for a vendor to alter your informatics platform - do it yourself in moments.
Benchling Registry and Molecular Biology for Antibody Engineering
Learn how our unified Registry, Molecular Biology, and Notebook applications work together to power antibody R&D. Register antibodies and chains; translate between DNA and protein sequences; analyze biochemical properties in real-time.
Benchling Registry and Molecular Biology for Cell and Gene Therapy
Learn how our unified applications work together to power cell and gene therapy R&D. Drag-and-drop plasmids into Notebook entries; parse sequence features to automatically register plasmids and their components.
Benchling: A Modern Informatics Platform for Large Molecule R&D
Benchling is natively built to model the complexity of large molecule R&D processes. It's a lasting informatics infrastructure that drives the development of your organization's scientific platform. Learn how Benchling will help you accelerate R&D and make better business decisions.
Benchling is natively built to model the complexity of biologics processes and samples and provide full experimental context across handoffs. It's a lasting informatics infrastructure that drives the development of your organization's scientific platform.
To Connect or to Integrate: The Role of Informatics in the Lab
Export functionality and other nominal “connectivity” features displace and stand in for actually useful functionality: meaningful integration between lab informatics software. Many informatics solutions bill themselves as integrated, but more often than not, that supposed integration falls short.
Biotech is booming, but R&D is held back by widespread inefficiencies. If biotech's going to mature in the same ways as other paradigm-shifting industries, it needs a new approach. As drugs continue to get more complex and as R&D costs continue to rise, biotech's only option is to industrialize.
How to Configure Registration Systems for Large Molecule R&D
From plasmids, to cell lines, to viral vectors, large molecule R&D involves many entities and parameters that have to be digitally modeled and interlinked. We've put together four guides on how to structure foundational registration systems for large molecule R&D.
Why Benchling’s a Gartner “Cool Vendor”: 5 Ways to Up-Level Biologics R&D
With pressure mounting on pharma to deliver new innovations faster than ever before, Benchling’s vision for measurable R&D in real-time has never been more pertinent. Read about Benchling’s five pillars to up-level your R&D organization.
6 Reasons Growing Biotechs Should Invest in Informatics Now
When it comes to informatics, it’s never too early to start deriving significant organizational benefits. Informatics is as much a short-term asset for growing companies as it is a long-term investment in developing your scientific platform.
Sharpening the Cutting Edge: Lab Software Platforms as a Competitive Advantage
No one should be complacent with legacy software, and thankfully, some biotech companies have realized that they don't have to be. The new generation of lab software rids science of grunt work, eliminating the human hours scientists used to waste transferring data between disparate software systems.
Over the past decade, there’s been fantastic progress in the quality of scientific tools for things like sequencing, synthesis, and genome engineering. Tools for managing scientific data, however, have barely changed; the industry still runs on paper, spreadsheets, and email.
CRISPR-EATING: a restriction/ligation method to inexpensively generate large sgRNA guide libraries
Andy Lane and his colleagues from Rebecca Heald’s lab at UC Berkeley describe a method to create sgRNA guide libraries for less than $100. Andy shares with Benchling how it works and also provides a detailed tutorials on how you can design your own guide RNA libraries.
Discovering novel CRISPR effectors and a new RNA toolbox
Omar Abudayyeh and Jonathan Gootenberg detail how, to uncover novel CRISPR-associated protein families, they mined all sequenced bacterial genomes on NCBI, looking for unknown proteins that cluster near known CRISPR sites.