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Benchling for Proteins & Peptides R&D

Track immunogenicity, model post-translational modification workflows, and manage protein and peptide candidate libraries.
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New classes of proteins and peptides are of significant research interest, but companies face several hurdles

This paper outlines the critical needs and complexities of protein and peptide R&D, and how Benchling has helped address these challenges for leading protein and peptide therapeutic companies.
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Proteins and Peptides Research

  • Track safety and immunogenicity throughout research

    • Create a centralized safety profile of lead protein and peptide candidates
    • Trace safety signals back to the primary, secondary, tertiary, and quaternary structure
    • Inform candidate optimization with instant access to the most up-to-date results

  • Create protein post-translational modification and peptide modification workflows

    • Design PTM workflows to suit your expression systems and protein engineering strategies
    • Organize the inventory of post-translationally modified proteins and peptides
    • Track critical structural and functional characteristics of precursors and mutants

  • Manage libraries of protein, peptides, epitopes and other related entities

    • Create a comprehensive single source library of all your protein and peptide-related entities
    • Link physical inventory and containers to library entities
    • Track lot specific results and complete sample history from the same interface

Proteins and Peptides Development

  • Seamlessly support DOE applications in protein process development

    • Identify critical quality attributes for protein and peptide therapeutics
    • Model and execute DOE studies to thoroughly evaluate your production process
    • Define process design space

  • Mitigate development risks such as aggregation and stability early

    • Identify molecule-specific stability liabilities
    • Design and execute experiments to study development liabilities throughout R&D
    • Develop risk mitigation plans and optimized processes with access to all results

  • Reduce COGS by increasing process efficiencies

    • Map entire production process on a single platform
    • Automate time-consuming and laborious steps
    • Monitor historical and real-time process performance

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