Cited Publications

  • A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

    Nature Biotechnology, 2016
    Yang Yang, Lili Wang, Peter Bell, Deirdre McMenamin, Zhenning He, John White, Hongwei Yu, Chenyu Xu, Hiroki Morizono, and Kiran Musunuru

    University of Pennsylvania, United States; Children’s National Medical Center, United States; Texas Heart Institute, United States
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  • A highly characterized yeast toolkit for modular, multipart assembly

    ACS Synthetic Biology, 2015
    Michael E Lee, William C DeLoache, Bernardo Cervantes, and John E Dueber

    University of California, Berkeley, United States; Lawrence Berkeley National Laboratory, United States
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  • A modular toolbox for gRNA–Cas9 genome engineering in plants based on the GoldenBraid standard

    Plant Methods, 2016
    Marta Vazquez-Vilar, Joan Miquel Bernabé-Orts, Asun Fernandez-del-Carmen, Pello Ziarsolo, Jose Blanca, Antonio Granell, and Diego Orzaez

    Universidad Politécnica de Valencia, Spain
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  • A Retroviral CRISPR-Cas9 System for Cellular Autism-Associated Phenotype Discovery in Developing Neurons

    Scientific Reports, 2016
    Michael R Williams, Catherine J Fricano-Kugler, Stephanie A Getz, Patrick D Skelton, Jeonghoon Lee, Christian P Rizzuto, Joseph S Geller, Meijie Li, and Bryan W Luikart

    Dartmouth College, United States
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  • An oxygen-sensitive toxin-antitoxin system

    Nature Communications, 2016
    O Marimon, J M Teixeira, T N Cordeiro, V W Soo, T L Wood, M Mayzel, I Amata, J García, A Morera, M Gay, M Vilaseca, V Y Orekhov, T K Wood, and M Pons

    University of Barcelona, Spain; The Pennsylvania State University, United States; Gothenburg University, Sweden; The Barcelona Institute of Science and Technology, Spain
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  • Blue light-mediated transcriptional activation and repression of gene expression in bacteria

    Nucleic Acids Research, 2016
    Premkumar Jayaraman, Kavya Devarajan, Tze Kwang Chua, Hanzhong Zhang, Erry Gunawan, and Chueh Loo Poh

    Nanyang Technological University, Singapore
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  • Calcium Signaling Throughout the Toxoplasma gondii Lytic Cycle. A Study Using Genetically Encoded Calcium Indicators

    The Journal of Biological Chemistry, 2015
    Lucas Borges-Pereira, Alexandre Budu, Ciara A McKnight, Christina A Moore, Stephen A Vella, Miryam A Hortua Triana, Jing Liu, Celia R S Garcia, Douglas A Pace, and Silvia N J Moreno

    University of Georgia, United States
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  • CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins

    Oncotarget, 2016
    Lars Björn Riecken, Ansgar Zoch, Ulrike Wiehl, Sabine Reichert, Ingmar Scholl, Yan Cui, Mirjana Ziemer, Ulf Anderegg, Christian Hagel, and Helen Morrison

    Fritz Lipmann Institute, Germany; University College London, United Kingdom; Universität Leipzig, Germany; University Medical Center Hamburg-Eppendorf, Germany
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  • CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.

    Oncotarget, 2016
    L B Riecken, A Zoch, U Wiehl, S Reichert, I Scholl, Y Cui, M Ziemer, U Anderegg, C Hagel, and H Morrison

    Fritz Lipmann Institute, Germany; University College London, United Kingdom; Universität Leipzig, Germany; University Medical Center Hamburg-Eppendorf, Germany
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  • CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells

    Cell Research, 2016
    Xiaojuan Liu, Yongping Zhang, Chen Cheng, Albert W Cheng, Xingying Zhang, Na Li, Changqing Xia, Xiaofei Wei, Xiang Liu, and Haoyi Wang

    The Chinese Academy of Sciences, People’s Republic of China; Capital Medical University, People’s Republic of China; University of Science and Technology of China, People’s Republic of China; The Jackson Laboratory, United States; University of Florida, United States; Beijing Cord Blood Bank, People’s Republic of China
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  • CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10

    Molecular Therapy, 2016
    Guo-Xiang Ruan, Elizabeth Barry, Dan Yu, Michael Lukason, Seng H Cheng, Abraham Scaria, and Sanofi Genzyme

    Sanofi Genzyme, United States
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  • CRISPR/Cas9-mediated integration enables TAG-eCLIP of endogenously tagged RNA binding proteins

    Methods, 2016
    Eric L Van Nostrand, Chelsea Gelboin-Burkhart, Ruth Wang, Gabriel A Pratt, Steven M Blue, and Gene W Yeo

    University of California at San Diego, United States; National University of Singapore, Singapore; A*STAR, Singapore
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  • Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.

    Mol Cell, 2016
    J F Dankert, G Rona, L Clijsters, P Geter, J R Skaar, K Bermudez-Hernandez, E Sassani, D Fenyö, B Ueberheide, R Schneider, and M Pagano

    New York University School of Medicine, United States
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  • Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays

    Free Radical Biology and Medicine, 2017
    Flávia Rezende, Kim-Kristin Prior, Oliver Löwe, Ilka Wittig, Valentina Strecker, Franziska Moll, Valeska Helfinger, Frank Schnütgen, Nina Kurrle, and Frank Wempe

    Goethe-University, Germany; University of Giessen, Germany
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  • Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

    Cell, 2016
    Diego Adhemar Jaitin, Assaf Weiner, Ido Yofe, David Lara-Astiaso, Hadas Keren-Shaul, Eyal David, Tomer Meir Salame, Amos Tanay, Alexander van Oudenaarden, and Ido Amit

    Weizmann Institute, Israel; Royal Netherlands Academy of Arts and Sciences, the Netherlands
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  • Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo

    Nucleic Acids Research, 2016
    Becky XH Fu, Robert P St Onge, Andrew Z Fire, and Justin D Smith

    Stanford University, United States
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  • Establishing a CRISPR–Cas-like immune system conferring DNA virus resistance in plants

    Nature Plants, 2015
    Xiang Ji, Huawei Zhang, Yi Zhang, Yanpeng Wang, and Caixia Gao

    University of Chinese Academy of Sciences, People’s Republic of China
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  • Fife organizes synaptic vesicles and calcium channels for high-probability neurotransmitter release

    The Journal of Cell Biology, 2016
    Joseph J Bruckner, Hong Zhan, Scott J Gratz, Monica Rao, Fiona Ukken, Gregory Zilberg, and Kate M O'Connor-Giles

    University of Wisconsin-Madison, United States
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  • Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease

    Progress in Retinal and Eye Research, 2016
    Sandy SC Hung, Tristan McCaughey, Olivia Swann, Alice Pébay, and Alex W Hewitt

    University of Melbourne, Melbourne, Australia; Monash University, Australia; University of Tasmania, Australia
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  • Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering

    Nature Biotechnology, 2016
    Andrew D Garst, Marcelo C Bassalo, Gur Pines, Sean A Lynch, Andrea L Halweg-Edwards, Rongming Liu, Liya Liang, Zhiwen Wang, Ramsey Zeitoun, and William G Alexander

    University of Colorado Boulder, United States; School of Chemical Engineering and Technology, People's Republic of China; Tianjin University, People's Republic of China
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  • Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells Using CRISPR-Cas9 EndonucleaseGenomic Disruption of VEGF-A in RPE

    Investigative Ophthalmology & Visual Science, 2016
    Glenn Yiu, Eric Tieu, Anthony T Nguyen, Brittany Wong, and Zeljka Smit-McBride

    University of California, Davis, United States; Duke University, United States
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  • High content analysis platform for optimization of lipid mediated CRISPR-Cas9 delivery strategies in human cells

    Acta Biomaterialia, 2016
    Benjamin Steyer, Jared Carlson-Stevermer, Nicolas Angenent-Mari, Andrew Khalil, Ty Harkness, and Krishanu Saha

    University of Wisconsin – Madison, United States
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  • High-throughput biochemical profiling reveals Cas9 off-target binding and unbinding heterogeneity

    bioRxiv, 2016
    Evan August Boyle, Johan Oscar Lennart Andreasson, Lauren Mallory Chircus, Samuel Henry Sternberg, Michelle Jennifer Wu, Chantal Katrin Guegler, Jennifer Anne Doudna, and William James Greenleaf

    Stanford University, United States; University of California, Berkeley, United States
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  • Highly-efficient Cpf1-mediated gene targeting in mice following high concentration pronuclear injection

    G3: Genes| Genomes| Genetics, 2016
    Dawn E Watkins-Chow, Gaurav K Varshney, Lisa J Garrett, Zelin Chen, Erin A Jimenez, Cecilia Rivas, Kevin S Bishop, Raman Sood, Ursula L Harper, and William J Pavan

    National Human Genome Research Institute, United States; Oklahoma Medical Research Foundation, United States
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  • McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation.

    Biochemistry, 2014
    D M Lord, Baran A Uzgoren, V W Soo, T K Wood, W Peti, and R Page

    Brown University, United States
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  • Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes

    Journal of Biological Chemistry, 2016
    V W Soo, Y Yosaatmadja, C J Squire, and W M Patrick

    Massey University, New Zealand; University of Auckland, New Zealand; University of Otago, New Zealand
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  • Metabolic engineering of Methanosarcina acetivorans for lactate production from methane

    Biotechnology and Bioengineering, 2016
    M J McAnulty, V G Poosarla, J Li, V W Soo, F Zhu, and T K Wood

    The Pennsylvania State University, United States
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  • Methods for optimizing CRISPR-Cas9 genome editing specificity

    Molecular Cell, 2016
    Josh Tycko, Vic E Myer, and Patrick D Hsu

    Editas Medicine, United States; Salk Institute for Biological Studies, United States
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  • Multiplexed Targeted Genome Engineering Using a Universal Nuclease-Assisted Vector Integration System

    American Chemical Society, 2016
    Alexander Brown, Wendy S Woods, and Pablo Perez-Pinera

    University of Illinois at Urbana-Champaign, United States
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  • Paired CRISPR/Cas9 guide-RNAs enable high-throughput deletion scanning (ScanDel) of a Mendelian disease locus for functionally critical non-coding elements

    bioRxiv, 2016
    Molly Gasperini, Gregory M Findlay, Aaron McKenna, Jennifer H Milbank, Choli Lee, Melissa D Zhang, Darren A Cusanovich, and Jay Shendure

    University of Washington, United States
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  • Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.

    Genes Dev., 2015
    S H Chiou, I P Winters, J Wang, S Naranjo, C Dudgeon, F B Tamburini, J J Brady, D Yang, B M Grüner, C H Chuang, D R Caswell, H Zeng, P Chu, G E Kim, D R Carpizo, S K Kim, and M M Winslow

    Stanford University School of Medicine, United States; Rutgers Robert Wood Johnson University Medical School, United States; University of California at San Francisco, United States
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  • Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design

    Genome biology, 2016
    Justin D Smith, Sundari Suresh, Ulrich Schlecht, Manhong Wu, Omar Wagih, Gary Peltz, Ronald W Davis, Lars M Steinmetz, Leopold Parts, and Robert P St Onge

    Stanford University, United States; European Bioinformatics Institute
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  • Regulation of cancer epigenomes with a histone-binding synthetic transcription factor

    npj Genomic Medicine, 2017
    David B Nyer, Rene M Daer, Daniel Vargas, Caroline Hom, and Karmella A Haynes

    Arizona State University, United States
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  • Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections

    Current Topics in Medicinal Chemistry, 2016
    V W Soo, B W Kwan, H Quezada, I Castillo-Juárez, B Pérez-Eretza, S J García-Contreras, M Martínez-Vázquez, T K Wood, and R García-Contreras

    Copilco Universidad, Mexico
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  • Reversing methanogenesis to capture methane for liquid biofuel precursors.

    Microbial Cell Factories, 2016
    V W Soo, M J McAnulty, A Tripathi, F Zhu, L Zhang, E Hatzakis, P B Smith, S Agrawal, H Nazem-Bokaee, S Gopalakrishnan, H M Salis, J G Ferry, C D Maranas, A D Patterson, and T K Wood

    The Pennsylvania State University, United States; Chinese Academic of Sciences, People’s Republic of China; Massey University, New Zealand
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  • Scarless Cas9 Assisted Recombineering (no‐SCAR) in Escherichia coli, an Easy‐to‐Use System for Genome Editing

    Current Protocols in Molecular Biology, 2017
    Christopher R Reisch and Kristala LJ Prather

    Massachusetts Institute of Technology, United States; University of Florida, United States
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  • Simple, Efficient CRISPR-Cas9-Mediated Gene Editing in Mice: Strategies and Methods

    Mouse Models for Drug Discovery: Methods and Protocols, 2016
    Benjamin E Low, Peter M Kutny, and Michael V Wiles
    The Jackson Laboratory, United States
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  • Spell checking nature: versatility of CRISPR/Cas9 for developing treatments for inherited disorders

    The American Journal of Human Genetics, 2016
    Daria Wojtal, Dwi U Kemaladewi, Zeenat Malam, Sarah Abdullah, Tatianna WY Wong, Elzbieta Hyatt, Zahra Baghestani, Sergio Pereira, James Stavropoulos, and Vincent Mouly

    The Hospital for Sick Children, Canada; University of Toronto, Canada; Sorbonne Universités, France; Institute of Child Health and Great Ormond Street Hospital, United Kingdom; University College London, United Kingdom
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  • Stem Cell Reports

    International Society for Stem Cell Research, 2015
    Alex Laperle, Cheston Hsiao, Michael Lampe, Jaime Mortier, Krishanu Saha, Sean P Palecek, and Kristyn S Masters

    University of Wisconsin – Madison, United States
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  • Structural characterization of encapsulated ferritin provides insight into iron storage in bacterial nanocompartments

    eLife, 2016
    Didi He, Sam Hughes, Sally Vanden-Hehir, Atanas Georgiev, Kirsten Altenbach, Emma Tarrant, C Logan Mackay, Kevin J Waldron, David J Clarke, and Jon Marles-Wright

    The University of Edinburgh, United Kingdom; Newcastle University, United Kingdom
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  • Targeted Gene Activation Using RNA-Guided Nucleases

    Springer, 2017
    Alexander Brown, Wendy S Woods, and Pablo Perez-Pinera

    University of Illinois at Urbana-Champaign, United States
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  • The impact of chromatin dynamics on Cas9-mediated genome editing in human cells

    ACS Synthetic Biology, 2016
    Rene M Daer, Josh P Cutts, David A Brafman, and Karmella A Haynes

    Arizona State University, United States
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  • The Intracellular Signaling Molecule Darpp-32 Is a Marker for Principal Neurons in the Cerebellum and Cerebellum-Like Circuits of Zebrafish

    Frontiers in Neuroanatomy, 2016
    Lena Robra and Vatsala Thirumalai

    National Centre for Biological Sciences, India
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  • The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation

    Cell reports, 2016
    Shaliny Ramachandran, Dania Haddad, Conglei Li, Michael X Le, Alexanda K Ling, Clare C So, Rajeev M Nepal, Jennifer L Gommerman, Kefei Yu, and Troy Ketela

    University of Toronto, Canada; Michigan State University, United States; University Health Network, Canada; University of Toronto, Canada
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  • Three-dimensional imaging of Drosophila motor synapses reveals ultrastructural organizational patterns

    Journal of Neurogenetics, 2016
    Hong Zhan, Joseph Bruckner, Ziheng Zhang, and Kate O'Conner-Giles

    University of Wisconsin-Madison, United States
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  • Visualizing adenosine to inosine RNA editing in single mammalian cells

    bioRxiv, 2016
    Ian A Mellis, Rohit K Gupte, Arjun Raj, and Sara H Rouhanifard

    University of Pennsylvania, United States
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  • Volatile Gas Production by Methyl Halide Transferase: An In Situ Reporter Of Microbial Gene Expression In Soil

    Environ. Sci. Technol., 2016
    Hsiao-Ying Cheng, Caroline A Masiello, George N Bennett, and Jonathan J Silberg

    Rice University, United States
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  • α-5 laminin synthesized by human pluripotent stem cells promotes self-renewal

    Stem cell reports, 2015
    Alex Laperle, Cheston Hsiao, Michael Lampe, Jaime Mortier, Krishanu Saha, Sean P Palecek, and Kristyn S Masters

    University of Wisconsin – Madison, United States
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