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Gene Therapy R&D Solution

Unlock the Promise of Gene Therapy and Gene Editing

Design, develop, and characterize novel gene therapies on a unified digital platform.

A new breed of software for breakthrough gene therapy R&D

Gene therapy is at the forefront of curing severe and often debilitating genetic disorders. New enabling technologies such as viral- and non-viral vectors, oncolytic viruses, and CRISPR are giving R&D teams more ways to innovate. Modern gene therapy requires investigation of a wide variety of genes of interest, engineering of delivery vectors, and optimization of vector production processes.

This necessitates a strong digital foundation to comprehensively characterize gene therapy candidates to bring the best products into the clinic. Traceability must be maintained across sequences, samples, experiments, and processes to generate actionable insights.

Join the hundreds of companies already using Benching

  • R&D Capabilities
  • Benefits

Gene Therapy R&D Solution

  • Design guide RNA and nucleases
    Design Guide RNA and Nucleases
    • Create guide RNA sequences with optimal on-target / off-target scoring
    • Analyze endonuclease sequences by using over a dozen cutting-edge in silico tools
    • Speed up gRNA design with built-in wizards and high-throughput features
  • Clone plasmids
    Clone Plasmids
    • Visualize plasmid maps with intuitive layouts and helpful feature highlighting tools
    • Insert custom DNA parts and share feature libraries with teammates
    • Perform high-throughput combinatorial cloning to design your plasmids efficiently
  • Produce delivery vectors
    • Iterate viral vector production runs faster with templatized stages and entries for recording steps
    • Capture large amounts of data quickly with structured results tables
    • Optimize process parameters with customizable visual dashboards
  • Perform analytical assays
    Perform analytical assays
    • Relay sample information and related results accurately and efficiently between teams
    • Execute analytical assays quickly and enforce SOPs with protocols and templates
    • Integrate directly with analytical instruments to centralize all assay results for easy analysis and visualization
  • Study efficacy and safety in vivo
    Study safety and efficacy in vivo
    • Plan in vivo studies and generate study protocols with collaborative tools
    • Monitor vivarium animals and directly track study measurements and calculations
    • Automatically link assay results to tissue samples with a unified data model
Design guide RNA and nucleases
Key Features
  • Create guide RNA sequences with optimal on-target / off-target scoring
  • Analyze endonuclease sequences by using over a dozen cutting-edge in silico tools
  • Speed up gRNA design with built-in wizards and high-throughput features
Clone plasmids
Key Features
  • Visualize plasmid maps with intuitive layouts and helpful feature highlighting tools
  • Insert custom DNA parts and share feature libraries with teammates
  • Perform high-throughput combinatorial cloning to design your plasmids efficiently
Key Features
  • Iterate viral vector production runs faster with templatized stages and entries for recording steps
  • Capture large amounts of data quickly with structured results tables
  • Optimize process parameters with customizable visual dashboards
Perform analytical assays
Key Features
  • Relay sample information and related results accurately and efficiently between teams
  • Execute analytical assays quickly and enforce SOPs with protocols and templates
  • Integrate directly with analytical instruments to centralize all assay results for easy analysis and visualization
Study efficacy and safety in vivo
Key Features
  • Plan in vivo studies and generate study protocols with collaborative tools
  • Monitor vivarium animals and directly track study measurements and calculations
  • Automatically link assay results to tissue samples with a unified data model

Gene Therapy R&D Solution

Benchling’s Gene Therapy R&D Solution is trusted by leading gene therapy innovators to accelerate their R&D. It enables scientists to study gene editing and gene therapy technologies at scale with improved productivity, intuitive collaboration, and contextual insights. This digital solution combines the capabilities of traditional ELN, LIMS, and molecular biology tools in a unified cloud solution that natively supports gene therapy R&D.

ACCELERATE YOUR R&D
  • Increase throughput of CRISPR sequence design and in-lab experimentation
    Scientists design CRISPR guides and plasmid sequences at scale and record large volumes of experimental data against critical vector products with high through tools and features.
  • Streamline collaboration between design, development, and analytical teams
    Scientists co-create CRISPR complexes, plan vector scale up studies, and share gene therapy product related samples and results across teams with fit-for purpose collaboration tools.
  • Uncover key insights based on complete view of gene therapy program metrics and milestones
    Scientists and executives study gene therapy product performance across R&D lifecycle, optimize vector production process parameters, and allocate scientific resources to key programs with customizable decision support tools.

Benchling delivers measurable results
for gene therapy R&D teams

  • Productivity
    60%
    Reduction in manual R&D tasks
  • Insights
    2x
    More confidence in data quality and completeness
  • Collaboration
    95%
    Improvement in cross-team data transfer
  • Informatics
    4.5x
    Typical ROI realized by Benchling customers
“It feels good to have something automated with just a single click, where before it took half an hour.”
Tim Hoogervorst


Technician

How We Deliver

  • Dedicated Expertise
    Our Customer Experience professionals possess deep scientific expertise, as well as training on information technology best practices. They apply this know-how to support gene therapy customers across a wide range of R&D teams.
  • Continuous Oversight
    Leverage Benchling's pre-implementation solutions consulting, professional implementation services, and customer success management expertise to help you get the most out of Benchling.
  • Focused R&D Support
    Take advantage of Benchling’s foundational implementation guides, developed by our Customer Experience team to support many gene therapy R&D functions, including:

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