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Application Note

Benchling for CRISPR Screening

This application note outlines the key challenges in CRISPR screening and how Benchling has helped leading life sciences companies overcome these hurdles.


CRISPR screening is a revolutionary methodology to identify genes of interest underlying a specific phenotype. CRISPR can be scaled up for screening applications because of the versatility of CRISPR/Cas9 in disrupting target DNA and the ease of gRNA/plasmid generation. However, large-scale use of this technology requires scientists to track the viability of edited cells, maximize editing efficiency, minimize off-target effects, optimize vector design, and improve transformation efficiency.

This application note provides:

  • An overview of challenges faced in CRISPR screening
  • How Benchling’s capabilities can help overcome these complexities and improve productivity
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