Boltz-2, from Boltz PBC, is the first fully open-source structure prediction model to combine 3D complex prediction with binding affinity estimation — moving beyond static structures toward a more complete picture of molecular interactions. It gives computational scientists more control over how predictions are generated.

Key capabilities:

• Protein-protein or protein-ligand multimer predictions

• Improved quality with fast and private MSA support (GPU-accelerated)

• License: MIT

Learn more about Boltz-2.